Zeroing in on the workings of tumor suppressor protein p53, the 'guardian of the genome'

The tumor suppressor protein p53 has been dubbed the "guardian of the genome" because it protects the DNA from stress or long-term damage by regulating the expression of numerous genes involved DNA repair, cell division and cell death. Now, FMI researchers have homed in on some of the mechanisms that regulate the activation of p53 target genes.