Researchers reveal structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT

In a study published in Science Advances, Dr. Cong Yao's team from the Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, reported a complete picture of TRiC-assisted tubulin/actin folding along TRiC ATPase cycle under the coordination of co-chaperone plp2 through cryoelectron microscopy (cryo-EM) analysis.