During the Rodent Research-1 (RR-1) mission flown to the ISS in 2014, videos that were taken to observe the mice revealed an unusual behavior that researchers are still working to understand. Young (16-week-old) but not old (32-week-old) mice engaged in a high level of "running" behavior beginning within two weeks of launch, according to research in Scientific Reports in 2019.
Source:
phys.org